The game crashes to desktop when entering the Nether after other multiple other mobs, Example: Zombie Piglin from a Zombie Piglin Farm, and Strays. That area of the Nether remains inaccessible unless the player travel thousands of blocks in the over world away from the affected area and enters the Nether. The player can then return to the affected area and restore access to it. Suspect that the new despawn mechanics are clearing the mobs that are causing the crashes when the player approaches from the Nether. This error destroys any farms that depend on sending mobs into the Nether.
Once the crash starts, even entering the Nether in Creative will crash the game. Possibly same bug as reported in