This has happened to me every single time I have been in the end, and I have not found a fix. Whenever I hit an enderman the game would just stop playing normally. The chunks stopped rendering and I couldn't interact with ANY blocks. Chests, levers, you name it. I also couldn't kill anymore endermen even though they were right in front of me and I was attempting to hitting them. From what I have observed this affects both creative and survival.