When changing game directory for any profile for any game version, saving changes result in a popup saying "The game directory you attempted to set has been locked by the current configuration, and has been reset to the default directory. If you're using a Gameband + Minecraft, please use a directory on the Gameband."

I personally don't think I have a Gameband since I do not know what it is, and I can't see any form of lock setting in the configuration.