During gameplay, the "Only Allow Trusted Skins" may switch itself during gameplay, causing weird skin displaying glitches (such as all players suddenly displaying as your skin, or a default skin). However, since you are able to switch the option during gameplay, this can be easily worked around.

Note: This can occur both ways, the option can turn itself off after leaving it on, and the option can turn on after leaving it off

The second screenshot below was taken after leaving the game idle for about an hour after the first was.